A Predicta Bioactive Bulk syringe which is a bioactive fill composite with brown tips
Predicta Bioactive Bulk paste a bioactive bulk-fill composite on one side and on another side we see the composite is being applied on a molar tooth model
Predicta Bioactive Bulk syringe A2/B2 regular viscosity, a bioactive bulk-fill composite with brown dispensing tip.
Predicta Bioactive Bulk syringe A2/B2 low viscosity, a bioactive bulk-fill composite with brown dispensing tip.
Predicta Bioactive Bulk syringe A1/B1 regular viscosity, a bioactive bulk-fill composite with brown dispensing tips
Predicta Bioactive Bulk syringe A1/B1 low viscosity, a bioactive bulk-fill composite with brown dispensing tips

Predicta® Bioactive Bulk Dual-Cure Composite

€129.37

SKU: S610 Category: Brand:

Dual-cure, bioactive universal composite for chairside bulk-fill restorative procedures. Unlimited cure depth, single-increment placement protocol.

Terms of delivery

Description

Predicta® Bioactive Bulk is a universal, dual-cure bioactive bulk-fill composite that streamlines restorative procedures while maintaining performance and longevity. It is designed to fill any size cavity preparation all the way up to the occlusal surface—without the need for layering—making it particularly effective for posterior restorations and as an amalgam substitute.

Moreover, this bioactive bulk-fill composite promotes long-term tooth health through the continuous release of calcium and phosphate ions. Additionally, it releases and recharges fluoride ions, contributing to remineralization and the formation of mineral apatite at the tooth-material interface. As a result, these bioactive properties help support tooth structure and reduce the risk of secondary caries.

Key Features of using Predicta Bioactive Bulk

  • Dual-cure for unlimited depth of cure – Ensures complete polymerization in deep preparations or under indirect restorations.

  • Fluorescent for natural appearance – Enhances esthetics and visibility under curing and diagnostic lights.

  • Multiple viscosities and shades – Available in flowable and packable consistencies to suit different clinical cases.

  • Highly radiopaque – Improves diagnostic confidence on X-rays.

  • Nanohybrid versatility – Offers excellent polishability and esthetic blending.

  • Strong and durable – Withstands occlusal forces in high-stress posterior zones.

  • Indicated for Class I–V restorations – Suitable for a broad range of clinical applications, from shallow to deep cavities.

  • Highly polishable – Maintains long-lasting surface luster and smoothness.

Predicta® Bioactive Bulk is compatible with all standard adhesive systems and is delivered in an easy-to-use syringe format for precise placement. Its ability to support minimally invasive dentistry while delivering long-term functional and esthetic outcomes makes it a valuable tool in any restorative workflow.

Download the brochure to learn more.

Predicta® Bioactive Bulk – Physical Properties Chart
Physical Property Regular
Viscosity		 Low
Viscosity
Light-cure setting time 40 sec 40 sec
Depth of light cure 4 mm 4 mm
Initial self-cure setting time at 37°C ≥5 min ≥5 min
Percentage filler by weight 67.6% 67.0%
Flexural strength, average 135 MPa 131.7 MPa
Compressive strength, average 355 MPa 355 MPa
Diametral tensile strength, average 52 MPa 52.0 MPa
Polymerization shrinkage, linear, light cured for 20 seconds 2.60% 3.40%
DC shrinkage at 37°C, with a two-minute self-cure followed by a 20-second light cure 1.52% 1.52%
Radiopacity 280 280
Surface hardness
(Barcol hardness)		 ≥70 ≥70
Wear resistance
(wear rate)		 0.50% 0.77%
Fluorescence Yes Yes
BPA Yes Yes
Manufacturer test results, Parkell Inc.

Additional references

https://www.nature.com/articles/s41598-025-86595-7

https://bmcoralhealth.biomedcentral.com/articles/10.1186/s12903-023-03814-1

https://www.nature.com/articles/s41405-024-00209-4

https://www.sciencedirect.com/science/article/pii/S0020653922002672

https://www.researchgate.net/publication/364401403_The_Cytotoxicity_and_Genotoxicity_of_Bioactive_Dental_Materials

For use by licensed dental professionals only.

Videos

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Predicta® Bioactive Bulk | Product insight by Dr. Manouchehr Kiaei
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Predicta® Bioactive Bulk | Product insight by Dr. Sjobbe Besseling
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Four Quick Tips for Using Predicta® Bioactive Bulk

Information

Description
File name
Language
Instruction for Use
English, Danish, German, Spanish, Finnish, French, Italian, Dutch, Norwegian, Swedish, Greek, Portuguese, Bulgarian, Hungarian, and Romanian
Safety Data Sheet
English, Danish, German, Greek, Spanish, Finnish, French, Italian, Norwegian, Polish, Dutch and Swedish
Safety Data Sheet
English, Danish, German, Greek, Spanish, Finnish, French, Italian, Norwegian, Polish, Dutch and Swedish
In vitro remineralization of adjacent interproximal enamel carious lesions in primary molars using a bioactive bulk-fill composite
English
Dentine Remineralisation Induced by “Bioactive” Materials through Mineral Deposition: An In Vitro Study
English
Mechanical properties of modern restorative "bioactive" dental materials - an in vitro study
English
The Cytotoxicity and Genotoxicity of Bioactive Dental Materials
English
The demineralization resistance and mechanical assessments of different bioactive restorative materials for primary and permanent teeth: an in vitro study
English
Predictable Management of a Deep Carious Lesion with Bioactive Restorative Materials
English
Bioactivity of Dental Restorative Materials: FDI Policy Statement
English
An in vitro micro‐CT assessment of bioactive restorative materials interfacial adaptation to dentin
English
Parkell® Bioactive Bulk Restorative - Release study by Uppsala University (Sweden)
English
Product Catalogue - Parkell Europe 2026 (EN)
English

“One of the best characteristics of Predicta is its dual-cure capability. This enables the dentist to fill the cavity in one increment, no matter how large the restoration may be. That saves time and minimizes the shrinkage tension in the tooth restoration interface. Being able to bulk fill in a single increment also minimizes the risk of contamination, as the whole procedure can be done much more quickly and efficiently.” – Manouchehr Kiaei, DDS, Sweden

“Predicta Bioactive Bulk is a unique restorative material; it is dual-curing, bioactive and well-suited for bulk application. There is no need for occlusal layering or to add a different composite on top of the bulk restoration. I love the ease with which large restorations can be made; it is a time-saver! The initial chemical curing process is nice and short, but not too short! My patients do not experience any pain after the application of the restoration. The restorations polish well and still look like new after several years.” –   Sjobbe Besseling, DDS, Netherlands

“Having something that is bioactive—something that lays down well and will create new hydroxyapatite or new tooth structure—is very beneficial.” –  Sheldon Seidman, DDS, USA

“I like Predicta Bulk because it fills in well and sets well. I am happy with how I’m able to trim and polish it, and the color is good. I have found that it flows to the walls of the preparation better than some of the other bulk-fills I have previously used.” – Sheldon Seidman, DDS, USA

“Predicta Bioactive Bulk has amazing esthetics while providing the security of dual-cure chemistry and bioactivity.” – Gregg Helvey, DDS, MAGD, CDT, USA

“It’s really the trifecta — you have a bulk-fill that’s dual-cure with bioactivity, which means you’ve got everything you need.” – Sheldon Seidman, DDS, USA

“At My Dental Company, we only use the highest quality of products. We are consistently looking for what products out there are the best. Parkell and their Predicta Bioactive line is one of those products and we love it. The more that we can create those ongoing and exceptional outcomes for our patients, that is really where we want to be in dentistry.” – Douglas Olson, DDS, USA

“I’ve been using Predicta Bulk to restore Class I and Class II cavities in molars and premolars for two years now. Predicta Bulk has consistently proven to have excellent properties and results. I placed over 2,000 restorations, many of which have been very large, and the failure rate of those restorations has been less than 0.5%.” – Manouchehr Kiaei, DDS, Sweden

“When I started using Predicta, I was pleasantly surprised by the excellent color adaptability of this composite. Using only the A2/B2 shade, I have been able to match almost every tooth shade.” – Manouchehr Kiaei, DDS, Sweden

Predicta Bioactive Bulk A1/B1 Regular Viscosity
SKU S615
Industry Dental
Category Universal Composite
Net Weight 9.25 g
Curing Type Dual curing
Predicta Bioactive Bulk A1/B1 Low Viscosity
SKU S610
Industry Dental
Category Universal Composite
Net Weight 9.25 g
Curing Type Dual curing
Predicta Bioactive Bulk A2/B2 Regular Viscosity
SKU S616
Industry Dental
Category Universal Composite
Net Weight 9.25 g
Curing Type Dual curing
Predicta Bioactive Bulk A2/B2 Low Viscosity
SKU S611
Industry Dental
Category Universal Composite
Net Weight 9.25 g
Curing Type Dual curing

FAQ

Bioactivity, colour adaptability and dual cure properties are the key features. Predicta Bioactive Bulk contains nano-hydroxiapatite, releases calcium and phosphate ions and releases and recharges fluoride. Bioactivity is known in the field to equate to stronger bonds between the restoration and tooth, penetration and filling of micro-gaps, reduction in sensitivity, guard against secondary caries, and the sealing of margins against microleakage. Predicta Bioactive Bulk is available in two translucent shades matching most natural tooth shades. It is a dual-cure resin composite that can be used to fill any size cavity preparation, all the way up to the occlusal surface, without any need for additional layering.

Predicta Bulk is a highly polishable universal composite, that can be used in all areas of the mouth, and is indicated for Class I through V restorations. Predicta Core is indicated for core build-ups and as a post cement. The addition of Zirconia helps provide a strong and stable support for crowns made of zirconia, lithium disilicate, porcelain, PFM and metal.

Materials must always be brought to room temperature prior to use.

The most likely reason a dual-cure composite doesn’t set is failure to double bleed.

Insert the cartridge into the dispensing gun or plunger, remove the shipping cap, then bleed material from both orifices onto a pad until it flows freely. Affix the mixing tip, express a pea-sized amount through it, then proceed immediately to placement.

Regular viscosity is used ideally for large restorations where stability is desirable and material drift is not. Low viscosity is recommended for smaller preps where the ability to flow and adapt into tighter spaces is preferred and for better adaptation of hard to access prep margins and line angles. Both HV and LV versions can be used in all restorative situations. These guidelines are an aid when choosing a bulk-fill that more closely matches your needs.

No, Predicta Bioactive Bulk is a nanohybrid, it is optimized for wear resistance and is highly polishable.

Like all dual-cure composites there will be some self-etching bonding agents that are not compatible with Predicta Bulk, however all good quality universal bonding agents are compatible with Predicta Bioactive Bulk.

Predicta Bioactive Bulk releases calcium and phosphate ions and releases and recharges fluoride ions to stimulate apatite formation and support the remineralization process at the tooth-material interface.

Predicta Bioactive Bulk is indicated for Class I, II, III, IV, and V restorations, including root surface cavities and post cementation.

Yes, due to its mechanical properties and ease of use Predicta Bioactive Bulk is the ideal amalgam substitute

Yes, Predicta Bioactive Bulk is suitable for the full restoration, it's designed to fill any size cavity preparation all the way to the occlusal surface without layering and is specifically noted as effective for posterior restorations. It does not require a capping layer of packable composite on top — it's a nanohybrid formulated for wear resistance and polishability on its own. It is however possible to add a packable composite on top.

No. It's a nanohybrid optimized for wear resistance and polishability on its own.

Two shades — A1/B1 and A2/B2 — each available in regular viscosity and low viscosity (LV), for four SKUs total: S615 (A1/B1 regular), S616 (A2/B2 regular), S610 (A1/B1 LV), S611 (A2/B2 LV). Each comes as a 5 ml hand-held syringe with 20 mixing tips.

Yes. Predicta Bioactive Bulk Low-Viscosity (LV) version may provide better adaptation when restoring small cavities in primary teeth on pediatric patients. The A1/B1 shade is the best colour match for youg patients.

Light-cure depth is 3–4 mm per light exposure of 20–40 seconds. Beyond that, the material self-cures to full depth at the bottom of the prep over approximately 5 minutes at mouth temperature — so full-depth cure doesn't rely on light penetration alone. No incremental layering is needed.

A dental curing light emitting blue light at 430–480 nm, with a minimum intensity of 600 mW/cm².

No, warming up before use is not required. However, bring up to room temperature before use

Regular viscosity composite is used ideally for large restorations where stability is desirable and material drift is not. Low viscosity composite is recommended for smaller preps where the ability to flow and adapt into tighter spaces is preferred and for better adaptation of hard to access prep margins and line angles. Both HV and LV versions can be used in all restorative situations. HV composite is also a better choice for core building while LV composite is ideal for post cementation. These guidelines are an aid when choosing a bulk-fill that more closely matches your needs.

Users report excellent colour adaptability of Predicta Bulk’s two shades, thanks to the material’s translucency that gives it “chameleon properties”, automatically blending with the surrounding tooth color. The A2/B2 shade matches most adult tooth shades while the A1/B1 shades is ideal for younger patients.

The most common cause with a dual-cure composite is failure to double bleed before use.

Yes, radiopacity is 280% relative to aluminum, improving diagnostic confidence on radiographs and helping distinguish restorations from recurrent decay.

Per the study "Mechanical properties of modern restorative 'bioactive' dental materials" (Scientific Reports):
Flexural strength: median 120.40 MPa — the highest among bioactive materials tested.

Modulus of elasticity: 7.27 ± 0.78 GPa
Diametral tensile strength: 47.08 MPa
Vickers hardness (baseline): approximately 47.0–48.8 HV

Per the study “An in vitro micro‐CT assessment of bioactive restorative materials interfacial adaptation to dentin” (Dental Research Journal) comparing three bioactive and a nanohybrid composite, Predicta Bulk followed by Activa Bioactive (Pulpdent) shows the lowest interfacial gap percentages at pulpal, axial. Gingival buccal and lingual walls.

Per the study “The demineralization resistance and mechanical assessments of different bioactive restorative materials for primary and permanent teeth: an in vitro study” (BDJ) comparing two bioactive and a non-bioactive composite, Predicta Bulk and Beautifil Kids (Shofu) demonstrated excellent resistance to demineralization while maintaining mechanical and physical properties comparable to the conventional composite.

Yes. Predicta® Bioactive Bulk contains 9.25 g of material for a retail price ranging between €105 (€11.35 per g) and €129 (€13.98 per gram). Its larger syringe size, dual-cure chemistry and ability to restore deep preparations up to the occlusal surface can make it a practical, cost-conscious bulk-fill composite for dental practices.

Clinical Literature

Explore published in vitro research evaluating Predicta® Bioactive Bulk, including studies of enamel and dentin remineralization, demineralization resistance, and mechanical properties.

In vitro remineralization of adjacent interproximal enamel carious lesions in primary molars
Phyo et al. · 2024 · BMC Oral Health

Phyo et al. (2025), in a study published in BMC Oral Health, assessed Predicta® Bioactive Bulk, a bioactive bulk-fill composite, and Filtek™ Z350 in artificial interproximal enamel carious lesions in extracted primary molars.

Key findings
  • Under the conditions tested, Predicta produced significantly greater surface microhardness recovery than Filtek™ Z350.
  • SEM images showed greater mineral deposition in the Predicta and high-viscosity glass ionomer groups than in the conventional resin-based composite group.
  • Predicta’s surface microhardness recovery and fluoride content were similar to those of the high-viscosity glass ionomer cement.
“

The highest percentage of surface microhardness recovery (%SMHR) was found in the Predicta® Bioactive Bulk group, which was significantly different from the Filtek™ Z350 group.

“

SEM images illustrated greater mineral deposition in the HVGIC and Predicta bioactive bulk-fill composite groups compared with conventional resin-based composite.

Study context

This was an in vitro study using extracted primary molars and artificially created enamel lesions. It does not establish clinical outcomes in patients.

Reference

Phyo, W. M., Saket, D., da Fonseca, M. A., Auychai, P., & Sriarj, W. (2024). In vitro remineralization of adjacent interproximal enamel carious lesions in primary molars using a bioactive bulk-fill composite. BMC Oral Health, 24, Article 37.

View Published Study

The demineralization resistance and mechanical assessments of different bioactive restorative materials for primary and permanent teeth
Ibrahim et al. · 2024 · BDJ Open

Ibrahim et al. compared Predicta® Bioactive Bulk-Fill with Beautifil Kids SA and a conventional non-bioactive flowable composite.

Key findings
  • Following pH cycling, Predicta Bioactive Bulk significantly increased the surface microhardness of dentin adjacent to the restoration.
  • The authors associated this result with the combined release of fluoride, calcium, and phosphate ions.
  • The tested bioactive materials demonstrated mechanical performance comparable to the non-bioactive control, while changes in color stability and surface roughness were generally similar across the materials.
“

It is expected that the synergetic effects between different remineralizing ions released by Predicta contributed to the significant increase in dentin microhardness.

“

The bioactive restorative materials tested here exhibited mechanical performance comparable to the control material with no bioactive ingredients.

Study context

This was an in vitro chemical secondary-caries model. The findings suggest potential resistance to demineralization but do not prove prevention of secondary caries in patients.

Reference

Ibrahim, M. S., Aldhafeeri, F. R., Banaemah, A. S., Alhaider, M. S., Al-Dulaijan, Y. A., & Balhaddad, A. A. (2024). The demineralization resistance and mechanical assessments of different bioactive restorative materials for primary and permanent teeth: An in vitro study. BDJ Open, 10, Article 30.

View Published Study

Mechanical properties of modern restorative “bioactive” dental materials: An in vitro study
Radwanski et al. · 2025 · Scientific Reports

Radwanski et al. compared Predicta Bulk Bioactive, Filtek Supreme Flow, Activa Bioactive Restorative, and Beautifil Flow Plus F00 and F03.

Key findings
  • Predicta recorded the highest flexural strength at 120.40 MPa.
  • Predicta recorded the highest modulus of elasticity at 7.27 GPa.
  • Its diametral tensile strength was 47.08 MPa, comparable to Filtek Supreme Flow at 47.74 MPa.
  • Predicta and Filtek showed significantly higher flexural and diametral tensile strength than the other tested materials and significantly lower sorption in saliva and alcohol.
“

The highest median value of FS was 120.40 MPa for Predicta Bulk Bioactive.

“

Predicta Bulk Bioactive and Filtek Supreme Flow exhibited significantly lower saliva and alcohol sorption.

Study context

This was an in vitro study and does not establish long-term clinical performance.

Reference

Radwanski, M., Zmyslowska-Polakowska, E., Osica, K., Krasowski, M., Sauro, S., Hardan, L., & Lukomska-Szymanska, M. (2025). Mechanical properties of modern restorative “bioactive” dental materials: An in vitro study. Scientific Reports, 15, Article 3552.

View Published Study

Bioactivity of dental restorative materials: FDI Policy Statement
Schmalz et al. · 2022· International Dental Journal

Schmalz et al. (2023), in a  review published in the International Dental Journal, provided the scientific background for the FDI Policy Statement on bioactive dental restorative materials. The authors clarified how the term “bioactive” should be used and what evidence is required to support bioactivity claims.

Key findings
  • Bioactivity should describe a beneficial, intended, and local interaction between a restorative material and target tissues such as enamel, dentin, or dental pulp.
  • For enamel and dentin, relevant bioactive effects may include reducing demineralization, slowing caries progression adjacent to restorations, and supporting remineralization.
  • Bioactive components should not compromise the material’s primary restorative purpose, including its mechanical properties, setting behavior, or clinical longevity.
“

The enamel, dentin, and dental pulp are regarded as the prime target tissues for bioactive restorative materials.

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Remineralisation of caries-affected dentin has been described adjacent to modified GICs or other ion-releasing materials.

Study context

This article is a concise review and provides the scientific background for an FDI policy statement. It establishes a framework for interpreting research on ion-releasing restorative materials and assessing whether bioactivity claims are scientifically supported.

Reference

Schmalz, G., Hickel, R., Price, R. B., & Platt, J. A. (2022). Bioactivity of dental restorative materials: FDI Policy Statement. International Dental Journal, 73(1), 21–27.

View Published Study

Clinical evaluation of bioactive composite resin in Class V lesions in high-risk caries patients: A randomized split-mouth trial
Rao et al. · 2025 · Journal of Conservative Dentistry and Endodontics

Rao et al. (2025) conducted a randomized split-mouth clinical trial comparing Predicta® Bioactive Bulk with 3M™ Filtek™ Bulk Fill Posterior Restorative in Class V carious lesions in 20 adults at high risk of caries. The restorations were evaluated using FDI criteria over a 12-month period.

Key findings
  • Both Predicta Bioactive Bulk and Filtek achieved a 100% restoration survival rate after one year.
  • No significant differences were found between the materials for marginal staining, marginal adaptation, fracture, retention, biological properties, or recurrence of the initial pathology.
  • Predicta Bioactive Bulk demonstrated clinical performance equivalent to the non-bioactive bulk-fill composite over the 12-month evaluation period.
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Predicta Bioactive Bulk and 3M™ Filtek™ Bulk Fill Posterior Restorative demonstrated equivalent effectiveness in the restoration of Class V caries in high-risk caries patients.

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Both bioactive and nonbioactive composites showed similar successful clinical performance when used to restore buccal caries in posterior permanent teeth of high caries risk patients, with a 100% survival rate after 1 year.

Study context

This randomized split-mouth clinical trial included 20 adults at high risk of caries and had a 12-month follow-up period. The findings support equivalent short-term clinical performance.

Reference

Rao, A., Anithakumari, R., Adarsha, M. S., Sudhanva, M. E., Vikram, R., & Naveen Kumar, N. (2025). Clinical evaluation of bioactive composite resin in Class V lesions in high-risk caries patients: A randomized split-mouth trial. Journal of Conservative Dentistry and Endodontics, 28(9), 905–910.

View Published Study

The cytotoxicity and genotoxicity of bioactive dental materials
Kunert et al. · 2022 · Cells

Kunert et al. (2022) evaluated the in vitro biocompatibility of six materials considered for vital pulp therapy, including Predicta® Bioactive Bulk. The researchers assessed cytotoxicity, DNA damage, apoptosis, and cell-cycle progression after exposing a human monocyte/macrophage cell line to material eluates for 24 and 48 hours.

Key findings
  • Predicta Bioactive Bulk showed no significant cytotoxicity or genotoxicity compared with the controls used in the study.
  • Predicta did not cause a significant increase in DNA damage or apoptosis and did not significantly alter cell-cycle progression in the tested human cell line.
  • The authors described these findings as favourable for potential indirect pulp-capping applications.
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Predicta Bioactive Bulk showed no significant cytotoxicity and genotoxicity compared to the controls used.

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Biodentine, ACTIVA BioACTIVE and Predicta Bioactive Bulk showed no significant increase in apoptosis in the tested cell line.

Study context

This was an in vitro study using material eluates and a human monocyte/macrophage peripheral blood cell line. It did not reproduce long-term clinical exposure, the dentin barrier, living pulp tissue, or the complete immune response found in patients.

Reference

Kunert, M., Rozpedek-Kaminska, W., Galita, G., Sauro, S., Bourgi, R., Hardan, L., Majsterek, I., & Lukomska-Szymanska, M. (2022). The cytotoxicity and genotoxicity of bioactive dental materials. Cells, 11(20), Article 3238.

View Published Study